Thomas Neylan, MD

Director of the Stress and Health Research Program
Principal Investigator
M_Psychiatry
+1 415 750-6961

Dr. Neylan is a Professor, In Residence in the Department of Psychiatry at the University of California, San Francisco. He is the Director of the Posttraumatic Stress Disorders (PTSD) Clinic and the Stress and Health Research Program at the San Francisco Veterans Affairs Medical Center. His research has focused on the role of sleep in emotion regulation, cognitive function, and metabolic health, in patients with PTSD, and more recently in aging populations with neurodegenerative disorders. He has been a Principal Investigator on multiple funded projects sponsored by the National Institutes of Health, the National Institute of Justice, the Department of Defense, the Department of Veterans Affairs, and several foundations.

His current funding includes projects examining the role of disturbed sleep on prefrontal executive control and emotion regulation in PTSD, the role of sleep and circadian factors in risk and resilience for developing PTSD in acutely traumatized patients seen in Emergency Departments, a trial examining effects of exercise for PTSD, a human-animal translational study examining the role of maladaptive myelination as a mechanism underpinning the structural and functional brain abnormalities associated with exposure to traumatic stress, and joint clinical and brain bank study of sleep/wake regulation in neurodegenerative tauopathies. Dr. Neylan directs the PTSD Research program at the San Francisco VA Medical Center and is the PI on the PTSD component of the Sierra Pacific Mental Illness Research, Education and Clinical Center which provides infrastructure support to investigators and fellows conducting PTSD research.

Publications: 

Factors associated with high functioning despite distress in post-9/11 veterans.

Rehabilitation psychology

McCaslin SE, Cloitre M, Neylan TC, Garvert DW, Herbst E, Marmar C

Positive impact of IPS supported employment on PTSD-related occupational-psychosocial functional outcomes: Results from a VA randomized-controlled trial.

Psychiatric rehabilitation journal

Mueller L, Wolfe WR, Neylan TC, McCaslin SE, Yehuda R, Flory JD, Kyriakides TC, Toscano R, Davis LL

Psychophysiological treatment outcomes: Corticotropin-releasing factor type 1 receptor antagonist increases inhibition of fear-potentiated startle in PTSD patients.

Psychophysiology

Jovanovic T, Duncan EJ, Kaye J, Garza K, Norrholm SD, Inslicht SS, Neylan TC, Mathew SJ, Iosifescu D, Rothbaum BO, Mayberg HS, Dunlop BW

Longitudinal association of PTSD symptoms and self-reported physical functioning among Veterans.

Journal of affective disorders

Ahmadian AJ, Neylan TC, Metzler T, Cohen BE

Factors associated with completing evidence-based psychotherapy for PTSD among veterans in a national healthcare system.

Psychiatry research

Maguen S, Li Y, Madden E, Seal KH, Neylan TC, Patterson OV, DuVall SL, Lujan C, Shiner B

Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers.

Journal of Alzheimer's disease : JAD

La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E

Further Exploring the Associations Between Sympathetic Activation, Fear of Sleep, and Insomnia Symptoms in Posttraumatic Stress Disorder.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Kanady JC, Maguen S, Neylan TC

Altered overnight levels of pro-inflammatory cytokines in men and women with posttraumatic stress disorder.

Psychoneuroendocrinology

K├╝ffer A, Straus LD, Prather AA, Inslicht SS, Richards A, Shigenaga JK, Madden E, Metzler TJ, Neylan TC, O'Donovan A

DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder.

Clinical epigenetics

Pape JC, Carrillo-Roa T, Rothbaum BO, Nemeroff CB, Czamara D, Zannas AS, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Dunlop BW, Binder EB

The role of co-neurotransmitters in sleep and wake regulation.

Molecular psychiatry

Oh J, Petersen C, Walsh CM, Bittencourt JC, Neylan TC, Grinberg LT

Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Mohlenhoff BS, Insel PS, Mackin RS, Neylan TC, Flenniken D, Nosheny R, Richards A, Maruff P, Weiner MW

Temporal Stability of Cognitive Functioning and Functional Capacity in Women with Posttraumatic Stress Disorder.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Gould F, Dunlop BW, Rosenthal JB, Iosifescu DV, Mathew SJ, Neylan TC, Rothbaum BO, Nemeroff CB, Harvey PD

Association among anterior cingulate cortex volume, psychophysiological response, and PTSD diagnosis in a Veteran sample.

Neurobiology of learning and memory

Young DA, Chao L, Neylan TC, O'Donovan A, Metzler TJ, Inslicht SS

Effects of Threat Context, Trauma History, and Posttraumatic Stress Disorder Status on Physiological Startle Reactivity in Gulf War Veterans.

Journal of traumatic stress

Niles AN, Luxenberg A, Neylan TC, Inslicht SS, Richards A, Metzler TJ, Hlavin J, Deng J, O'Donovan A

Cognitive Behavioral Therapy for Insomnia Reduces Fear of Sleep in Individuals With Posttraumatic Stress Disorder.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Kanady JC, Talbot LS, Maguen S, Straus LD, Richards A, Ruoff L, Metzler TJ, Neylan TC

Patterns of Zolpidem Use in Male and Female Veterans Following Revised FDA Dosing Guidelines.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

Inslicht SS, Neylan TC

Posttraumatic stress disorder, depression, and suicidal ideation in veterans: Results from the mind your heart study.

Psychiatry research

Arenson MB, Whooley MA, Neylan TC, Maguen S, Metzler TJ, Cohen BE

The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans.

Journal of affective disorders

Young DA, Neylan TC, O'Donovan A, Metzler T, Richards A, Ross JA, Inslicht SS

Deployment Anxiety Reduction Training: A Pilot Study of Acceptability and Feasibility in Current or Recent Active Duty Service Members.

Military medicine

McCaslin SE, Herbst ED, Armitage NH, Allen I, Neylan T, Becket-Davenport C, Choucroun G, Best S, Inslicht SS

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Journal of neuropathology and experimental neurology

Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT

Sleep and hypothalamic pituitary adrenal axis responses to metyrapone in posttraumatic stress disorder.

Psychoneuroendocrinology

Inslicht SS, Rao MN, Richards A, O'Donovan A, Gibson CJ, Baum T, Metzler TJ, Neylan TC

Subjective Sleep Related to Post Traumatic Stress Disorder Symptoms among Trauma-Exposed Men and Women.

Behavioral sleep medicine

Gibson CJ, Richards A, Villanueva C, Barrientos M, Neylan TC, Inslicht SS

Veterans Group Exercise: A randomized pilot trial of an Integrative Exercise program for veterans with posttraumatic stress.

Journal of affective disorders

Goldstein LA, Mehling WE, Metzler TJ, Cohen BE, Barnes DE, Choucroun GJ, Silver A, Talbot LS, Maguen S, Hlavin JA, Chesney MA, Neylan TC

Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy.

Sleep

Walsh CM, Ruoff L, Walker K, Emery A, Varbel J, Karageorgiou E, Luong PN, Mance I, Heuer HW, Boxer AL, Grinberg LT, Kramer JH, Miller BL, Neylan TC

A 12-week integrative exercise program improves self-reported mindfulness and interoceptive awareness in war veterans with posttraumatic stress symptoms.

Journal of clinical psychology

Mehling WE, Chesney MA, Metzler TJ, Goldstein LA, Maguen S, Geronimo C, Agcaoili G, Barnes DE, Hlavin JA, Neylan TC

Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?

Biological psychiatry

Krystal JH, Davis LL, Neylan TC, Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TC, Huang GD

PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Breen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ

Suicidality and associated risk factors in outpatients attending a general medical facility in rural Kenya.

Journal of affective disorders

Ongeri L, McCulloch CE, Neylan TC, Bukusi E, Macfarlane SB, Othieno C, Ngugi AK, Meffert SM

Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder.

Biological psychiatry

Dunlop BW, Binder EB, Iosifescu D, Mathew SJ, Neylan TC, Pape JC, Carrillo-Roa T, Green C, Kinkead B, Grigoriadis D, Rothbaum BO, Nemeroff CB, Mayberg HS

Editorial Comment: Predictors of Post-Traumatic Stress Disorder in Acutely Traumatized Older Adults.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Neylan TC

Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report.

Alzheimer's & dementia (New York, N. Y.)

Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC, Tosun D, Veitch DP, Jack CR, Decarli C, Saykin AJ, Grafman J, Neylanthe TC

It Is Time to Address the Crisis in the Pharmacotherapy of Posttraumatic Stress Disorder: A Consensus Statement of the PTSD Psychopharmacology Working Group.

Biological psychiatry

Krystal JH, Davis LL, Neylan TC, A Raskind M, Schnurr PP, Stein MB, Vessicchio J, Shiner B, Gleason TD, Huang GD

Impact of Killing in War: A Randomized, Controlled Pilot Trial.

Journal of clinical psychology

Maguen S, Burkman K, Madden E, Dinh J, Bosch J, Keyser J, Schmitz M, Neylan TC

Symptom Presentation and Prescription of Sleep Medications for Veterans With Posttraumatic Stress Disorder.

The Journal of nervous and mental disease

Greenbaum MA, Neylan TC, Rosen CS

Brief Report: Sexual Violence Against HIV-Positive Women in the Nyanza Region of Kenya: Is Condom Negotiation an Instigator?

Journal of acquired immune deficiency syndromes (1999)

Onu CC, Dworkin SL, Ongeri LG, Oyaro P, Neylan TC, Cohen CR, Bukusi EA, Rota G, Meffert SM

Sleep and Cognitive Performance From Teens To Old Age: More Is Not Better.

Sleep

Richards A, Inslicht SS, Metzler TJ, Mohlenhoff BS, Rao MN, O'Donovan A, Neylan TC

What I have changed my mind about and why.

European journal of psychotraumatology

Yehuda R, Spiegel D, Southwick S, Davis LL, Neylan TC, Krystal JH

Current posttraumatic stress disorder and exaggerated threat sensitivity associated with elevated inflammation in the Mind Your Heart Study.

Brain, behavior, and immunity

O'Donovan A, Ahmadian AJ, Neylan TC, Pacult MA, Edmondson D, Cohen BE

Observational Evidence for Buprenorphine's Impact on Posttraumatic Stress Symptoms in Veterans With Chronic Pain and Opioid Use Disorder.

The Journal of clinical psychiatry

Seal KH, Maguen S, Bertenthal D, Batki SL, Striebel J, Stein MB, Madden E, Neylan TC

Health impact of human rights testimony: harming the most vulnerable?

BMJ global health

Meffert SM, Shome S, Neylan TC, Musalo K, Fineberg HV, Cooke MM, Volberding PA, Goosby EP

Rest-activity rhythm disruption in progressive supranuclear palsy.

Sleep medicine

Walsh CM, Ruoff L, Varbel J, Walker K, Grinberg LT, Boxer AL, Kramer JH, Miller BL, Neylan TC

Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans.

Journal of the American Heart Association

Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE

Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.

eNeuro

Schwartz MD, Nguyen AT, Warrier DR, Palmerston JB, Thomas AM, Morairty SR, Neylan TC, Kilduff TS