Irina Strigo, PhD

Principal Investigator
M_Psychiatry
[email protected]
+1 415 221-4810 ext. 5138

Irina Strigo, Ph.D. is Associate Professor in the Department of Psychiatry at UCSF and UCSD and Research Physiologist at the U.S. Department of Veterans Affairs. She received her research training from Columbia University (Radiology), Barrow Neurological Institute (Neurosurgery) and UC San Diego (Psychiatry). She received her Ph.D. and B.Sc. in Physiology from McGill University, Montreal, Canada.

Our group investigates brain networks that process pain and emotion in individuals with depressive, anxiety disorders, chronic pain and traumatic brain injury. In addition we seek to understand how individual differences in pain response relate to pain chronification. This research has been funded by the National Alliance for Research in Schizophrenia and Depression (NARSAD), National Institute of Mental Health (NIMH) and the U.S. Department of Veterans Affairs.

Publications: 

Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.

PloS one

Lerman I, Davis B, Huang M, Huang C, Sorkin L, Proudfoot J, Zhong E, Kimball D, Rao R, Simon B, Spadoni A, Strigo I, Baker DG, Simmons AN

Fear as a translational mechanism in the psychopathology of anorexia nervosa.

Neuroscience and biobehavioral reviews

Murray SB, Strober M, Craske MG, Griffiths S, Levinson CA, Strigo IA

Multimodal canonical correlation reveals converging neural circuitry across trauma-related disorders of affect and cognition.

Neurobiology of stress

Stout DM, Buchsbaum MS, Spadoni AD, Risbrough VB, Strigo IA, Matthews SC, Simmons AN

An exploratory examination of reappraisal success in depressed adolescents: Preliminary evidence of functional differences in cognitive control brain regions.

Journal of affective disorders

LeWinn KZ, Strigo IA, Connolly CG, Ho TC, Tymofiyeva O, Sacchet MD, Weng HY, Blom EH, Simmons AN, Yang TT

An Interdisciplinary Pain Rehabilitation Program for Veterans with Chronic Pain: Description and Initial Evaluation of Outcomes.

Pain research & management

Anamkath NS, Palyo SA, Jacobs SC, Lartigue A, Schopmeyer K, Strigo IA

The clinical application of fMRI data in a single-patient diagnostic conundrum: Classifying brain response to experimental pain to distinguish between gastrointestinal, depressive and eating disorder symptoms.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Strigo IA, Murray SB, Simmons AN, Bernard RS, Huang JS, Kaye WH

Neural differences underlying face processing in veterans with TBI and co-occurring TBI and PTSD.

Journal of affective disorders

Bomyea J, Matthews SC, Buchsbaum MS, Spadoni AD, Strigo IA, Simmons AN

Association of Traumatic Brain Injury With Chronic Pain in Iraq and Afghanistan Veterans: Effect of Comorbid Mental Health Conditions.

Archives of physical medicine and rehabilitation

Seal KH, Bertenthal D, Barnes DE, Byers AL, Strigo I, Yaffe K

Slow brushing reduces heat pain in humans.

European journal of pain (London, England)

Liljencrantz J, Strigo I, Ellingsen DM, Krämer HH, Lundblad LC, Nagi SS, Leknes S, Olausson H

Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease.

Journal of pediatric gastroenterology and nutrition

Huang JS, Terrones L, Simmons AN, Kaye W, Strigo I

Interoception, homeostatic emotions and sympathovagal balance.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Strigo IA, Craig AD

Faking bad: The neural correlates of feigning memory impairment.

Neuropsychology

Kosheleva E, Spadoni AD, Strigo IA, Buchsbaum MS, Simmons AN

Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression.

Biological psychiatry

Ho TC, Connolly CG, Henje Blom E, LeWinn KZ, Strigo IA, Paulus MP, Frank G, Max JE, Wu J, Chan M, Tapert SF, Simmons AN, Yang TT

Evidence for acute central sensitization to prolonged experimental pain in posttraumatic stress disorder.

Pain medicine (Malden, Mass.)

Moeller-Bertram T, Strigo IA, Simmons AN, Schilling JM, Patel P, Baker DG

Too hard to control: compromised pain anticipation and modulation in mild traumatic brain injury.

Translational psychiatry

Strigo IA, Spadoni AD, Lohr J, Simmons AN

Neurosubstrates of remission following prolonged exposure therapy in veterans with posttraumatic stress disorder.

Psychotherapy and psychosomatics

Simmons AN, Norman SB, Spadoni AD, Strigo IA

Greater anterior insula activation during anticipation of food images in women recovered from anorexia nervosa versus controls.

Psychiatry research

Oberndorfer T, Simmons A, McCurdy D, Strigo I, Matthews S, Yang T, Irvine Z, Kaye W

The effects of temporal unpredictability in anticipation of negative events in combat veterans with PTSD.

Journal of affective disorders

Simmons AN, Flagan TM, Wittmann M, Strigo IA, Matthews SC, Donovan H, Lohr JB, Paulus MP

Altered insula activation during pain anticipation in individuals recovered from anorexia nervosa: evidence of interoceptive dysregulation.

The International journal of eating disorders

Strigo IA, Matthews SC, Simmons AN, Oberndorfer T, Klabunde M, Reinhardt LE, Kaye WH

Altered insula activation in anticipation of changing emotional states: neural mechanisms underlying cognitive flexibility in Special Operations Forces personnel.

Neuroreport

Simmons AN, Fitzpatrick S, Strigo IA, Potterat EG, Johnson DC, Matthews SC, Orden KF, Swain JL, Paulus MP

The parametric, psychological, neuropsychological, and neuroanatomical properties of self and world evaluation.

PloS one

Simmons AN, Thayer RE, Spadoni AD, Matthews SC, Strigo IA, Tapert SF

Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans.

Biology of mood & anxiety disorders

Simmons AN, Matthews SC, Strigo IA, Baker DG, Donovan HK, Motezadi A, Stein MB, Paulus MP

Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study.

Psychiatry research

Brown GG, Lee JS, Strigo IA, Caligiuri MP, Meloy MJ, Lohr J

Pain and post traumatic stress disorder - review of clinical and experimental evidence.

Neuropharmacology

Moeller-Bertram T, Keltner J, Strigo IA

Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women.

The International journal of eating disorders

Oberndorfer TA, Kaye WH, Simmons AN, Strigo IA, Matthews SC

Anxiety positive subjects show altered processing in the anterior insula during anticipation of negative stimuli.

Human brain mapping

Simmons AN, Stein MB, Strigo IA, Arce E, Hitchcock C, Paulus MP

Dynamical principles of emotion-cognition interaction: mathematical images of mental disorders.

PloS one

Rabinovich MI, Muezzinoglu MK, Strigo I, Bystritsky A

Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence.

Biological psychiatry

Strigo IA, Simmons AN, Matthews SC, Grimes EM, Allard CB, Reinhardt LE, Paulus MP, Stein MB

Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers.

Psychiatry research

Matthews SC, Simmons AN, Strigo IA, Arce E, Stein MB, Paulus MP

Adolescents with major depression demonstrate increased amygdala activation.

Journal of the American Academy of Child and Adolescent Psychiatry

Yang TT, Simmons AN, Matthews SC, Tapert SF, Frank GK, Max JE, Bischoff-Grethe A, Lansing AE, Brown G, Strigo IA, Wu J, Paulus MP

Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression.

Psychiatry research

Matthews S, Simmons A, Strigo I, Gianaros P, Yang T, Paulus M

Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain.

Archives of general psychiatry

Strigo IA, Simmons AN, Matthews SC, Craig AD, Paulus MP

Heritability of anterior cingulate response to conflict: an fMRI study in female twins.

NeuroImage

Matthews SC, Simmons AN, Strigo I, Jang K, Stein MB, Paulus MP

Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects.

Biological psychiatry

Simmons A, Strigo I, Matthews SC, Paulus MP, Stein MB

Feelings of warmth correlate with neural activity in right anterior insular cortex.

Neuroscience letters

Olausson H, Charron J, Marchand S, Villemure C, Strigo IA, Bushnell MC

Visceral and cutaneous pain representation in parasylvian cortex.

Neuroscience letters

Strigo IA, Albanese MC, Bushnell MC, Duncan GH

Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome.

Pain

Pukall CF, Strigo IA, Binik YM, Amsel R, Khalifé S, Bushnell MC

Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.

American journal of physiology. Regulatory, integrative and comparative physiology

Hua le H, Strigo IA, Baxter LC, Johnson SC, Craig AD

The effects of racemic ketamine on painful stimulation of skin and viscera in human subjects.

Pain

Strigo IA, Duncan GH, Bushnell MC, Boivin M, Wainer I, Rodriguez Rosas ME, Persson J

Differentiation of visceral and cutaneous pain in the human brain.

Journal of neurophysiology

Strigo IA, Duncan GH, Boivin M, Bushnell MC

Unmyelinated tactile afferents signal touch and project to insular cortex.

Nature neuroscience

Olausson H, Lamarre Y, Backlund H, Morin C, Wallin BG, Starck G, Ekholm S, Strigo I, Worsley K, Vallbo AB, Bushnell MC

Psychophysical analysis of visceral and cutaneous pain in human subjects.

Pain

Strigo IA, Bushnell MC, Boivin M, Duncan GH

Effect of ambient temperature on human pain and temperature perception.

Anesthesiology

Strigo IA, Carli F, Bushnell MC